Dinutuximab beta was approved by the European Commission in May 2017 “for the treatment of high-risk neuroblastoma in patients aged 12 months and above who have previously received induction chemotherapy and achieved at least a partial response followed by myeloablative therapy and stem cell transplantation.” It is also approved in the EU for patients “with a history of relapsed or refractory neuroblastoma with or without residual disease.” Dinutuximab beta currently is investigational in the US and is being evaluated with IL-2 and isotretinoin for treatment of neuroblastoma (80). The gene discussed is IL2; the disease is neuroblastoma.