TMPRSS2 and posterior cortical atrophy: Another promising urinary biomarker test is encoded by a fusion gene formed as a result of a translation between the androgen-regulated trans-membrane protease, serine 2 (TMPRSS2) gene transcriptional promoter and the ETS-related oncogene (ERG), resulting in an androgen-regulated TMPRSS2-ERG fusion gene that is highly PCa-specific (14).