We previously reported that postoperative thyroglobulin-doubling rates in PTC patients aged ≤18 years were significantly smaller or negative than their hypothetical tumor volume-doubling rates (hTV-DRs) before presentation (described below), irrespective of radioactive iodine administration, indicating that the growth of PTCs in children and adolescents spontaneously slowed or even regressed postoperatively [13]. This evidence concerns the gene TG and neoplasm.