SIRT1 and non-small cell lung carcinoma: These findings strongly suggest a link between miR-204-5p and SIRT-1:-3/CAV-1 expression in mediating the apoptotic effects of TL in NSCLC and indicate a novel mechanism by which TL, via miR204-5p up-regulation and associated CAV-1 down-regulation, triggers the activation of mitochondria-mediated apoptosis in NSCLC (Figure 7).