More importantly, mRNA expression of both Cav-1 and Sirt-1 significantly (p < 0.05) decreased concomitantly with miR204-5p upregulation (Figure 4B) implying that elevated miR204-5p RNA is associated with TL-induced cytotoxicity in A549 and NCI-H460 lung cancer cells. This evidence concerns the gene SIRT1 and lung carcinoma.