So, we reasoned that a tumor showing by MLPA e.g. HER1 and HER2 amplification, could be due to a 100% of cells with HER1-HER2 co-amplification, 50% of cells with solely HER1 amplification and 50% with solely HER2 amplification, or any combination in-between. Here, ERBB2 is linked to neoplasm.