RB1 and Wilson disease: Double homozygous deletions of Rb1 and Men1 developed WD G1/G2 PanNETs while double homozygous deletions of Rb1 and Trp53 developed WD G3 PanNETs and double homozygous deletions of Men1 and Trp53 did not show a synergistic effect on islet tumorigenesis, as reported earlier [54].