Using the same set of paraffin-embedded pathological HNSCC samples (Supplementary Table 2) that were tested for S100A8 and S100A9, expression and distribution of LYPLA1 was visualized by immunohistochemistry according to the scheme described earlier (Figures 3 and Figures 8A–8C). Here, S100A9 is linked to head and neck squamous cell carcinoma.