The gene EVI2A, as the human homolog of mouse genes, may be associated with other proteins in the membrane as a part of a cell surface receptor complex [37]; EVI2A has been shown to be an oncogene [38]; EVI2A is highly expressed in oral tongue squamous cell carcinoma [39] and osteosarcoma [40] and is a risk factor for cancer prognosis. The gene discussed is EVI2A; the disease is osteosarcoma.