In this study, we selected eight lncRNAs (HULC, MALAT1, Linc00152, PTENP1, PTTG3P, SPRY4-IT1, UBE2CP3, and UCA1) from previously published HCC-related studies [11, 14, 15, 18–20] and assessed their expressions in serum of 129 HCC patients, 49 patients with LC, 27 patients with CHB, and 93 healthy controls. This evidence concerns the gene SPRY4 and hepatocellular carcinoma.