Our data revealed that seven lncRNAs (HULC, MALAT1, Linc00152, PTTG3P, SPRY4-IT1, UBE2CP3, and UCA1) were markedly high expressed in serum of HCC patients compared with healthy controls, which are similar to some previous studies [11, 18, 21–23]. This evidence concerns the gene SPRY4 and hepatocellular carcinoma.