Therefore, in this study, we initially enrolled PTENP1, PTTG3P, and other six lncRNAs (HULC, MALAT1, Linc00152, SPRY4-IT1, UBE2CP3, and UCA1) which have been already reported to be promising serum markers for HCC [9, 11, 15]. The gene discussed is SPRY4; the disease is hepatocellular carcinoma.