As shown in Figure 3(b) and Table 6, ROC analysis showed that AFP (AUC: 0.811; 95% CI: 0.761-0.861), HULC (AUC: 0.756; 95% CI: 0.702-0.810), MALAT1 (AUC: 0.733; 95% CI: 0.676-0.790), Linc00152 (AUC: 0.877; 95% CI: 0.835-0.918), PTTG3P (AUC: 0.768; 95% CI: 0.715-0.820), SPRY4-IT1 (AUC: 0.768; 95% CI: 0.715-0.821), UBE2CP3 (AUC: 0.756; 95% CI: 0.702-0.810), and UCA1 (AUC: 0.809; 95% CI: 0.761-0.857) had a significantly predictive value for distinguishing HCC patients from CHB and LC patients and HC. Here, SPRY4 is linked to hepatocellular carcinoma.