BRCA1 and breast cancer: Among 37 patients with triple-negative disease who were 40 years of age or younger, 12 (32.4%) were positive; all except 2 were in BRCA1. Among the patients with triple-negative disease who have a family history of breast cancer diagnosed at an age <50 (n = 12), 5 (41.7%) were BRCA1- or BRCA2-positive.