We found that upregulated genes PIK3CG, CSF1R, SPP1, and CCND1 and downregulated genes EGFR and VWF were significantly enriched in PI3K-Akt signaling pathway involved in VSs development, which can increase schwannoma cell proliferation, survival, and cell-matrix adhesion acting [4–6]. This evidence concerns the gene AKT1 and schwannoma.