In the nucleus, SNHG15 can interact with the zinc finger domain of Slug, inhibiting Slug ubiquitination, and then the redundant Slug proteins inhibit E-cadherin transcription, promote the epithelial–mesenchymal transition (EMT), and stimulate the invasion and metastasis of the colon, breast, and renal cancer cells [22, 34]. The gene discussed is SNAI2; the disease is renal carcinoma.