In pancreatic cancer, SNHG15 can also bind to the enhancer of zeste homolog 2 and inhibit the expression of p15 and the Kruppel-like factor 2 by zeste homolog 2-mediated H3 lysine 27 trimethylation modification and finally promote the proliferation of pancreatic cancer cells [20]. Here, KLF2 is linked to familial pancreatic carcinoma.