In the present study, we found that SNHG15 expression correlated with lymphatic metastasis, distant metastasis, and later TNM stages, suggesting that (1) increased expression of SNHG15 may be closely related to the advanced characteristics of cancer; (2) clarification of the relationships between SNHG15 expression and clinical parameters may allow the identification of the patient population who can potentially benefit from chemotherapy. This evidence concerns the gene SNHG15 and cancer.