The results suggested that the increase of SNHG15 expression in the digestive subgroup (including HCC, CRC, GC, and PC) and RCC, TC, BC, and OC subgroup was significantly associated with a shorter OS, which suggested that SNHG15 may be a reliable prognostic biomarker for cancers of the digestive, urinary, thyroid, and reproductive organs. The gene discussed is SNHG15; the disease is pachyonychia congenita.