AKT3 and megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2: Among these 10 genes, AKT3 gene, disrupted in P11, is associated with Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 (MPPH2) which is characterized by ID, megalencephaly and bilateral perisylvian polymicrogyria.