C5 and COVID-19: Preliminary case reports from “hot zones” in Italy outlined the anecdotal success by compassionate use of the complement C3 inhibitor AMY-101 (Amyndas Pharmaceuticals, Glyfada, Greece) and by administration of the anti-C5 monoclonal antibody eculizumab (Soliris; Alexion, Boston, MA) in the rescue of critically ill COVID-19 patients (25, 26).