Thus, in summary, in case of inflammatory pathway leading to cytokine storm, pro-inflammatory factors such as IL-6, IL-8, IL-1β, and GM-CSF and chemokines such as CCL2, CCL-5, IP-10, and CCL3, together with reactive oxygen species have been attributed to cause acute respiratory distress syndrome (ARDS) leading to pulmonary fibrosis and death. The gene discussed is CXCL8; the disease is acute respiratory distress syndrome.