CD8A and infection: We transferred naïve splenic TG6 or OT-1 CD8+ T cells from TCR transgenic H-2b/d mice into T and B cell deficient H-2b/d (B6 Rag2−/− × BALB/c Rag2−/−) mice one day prior to infection, and monitored parasite load and T cell responses 6–8 weeks later (Figure 1A).