CD209 and rheumatoid arthritis: Here we show that Tofacitinib inhibition of Mo-DC differentiation translate into a functional impairment, as observed by the inhibition of both receptor-mediated endocytosis and macropinocytosis in HC and PsA, and to a lesser extent, in RA This effect may be mediated, in part, through the observed decrease in CD209 expression in response to Tofacitinib, consistent with previous studies which have demonstrated that the presence of CD209 on the surface of DC is required for DC antigen uptake (65).