We have previously shown in Mo-DC that NOX5 inhibition, both pharmacologically and with siRNA technology, significantly decrease STAT5 phosphorylation (8), in addition it has been shown that STAT5 phosphorylation is inhibited by Tofacitinib in T cells (68) and lymphocytes from RA patients (69). The gene discussed is NOX5; the disease is rheumatoid arthritis.