C5AR1 and infection: As shown in Figure 3A, neutrophil numbers significantly increased in the spleen, MLN, and peritoneum in wt and C5ar1−/− mice after infection Importantly, while neutrophil numbers were similar in the spleen and MLN of wt and C5ar1−/− mice, we found slightly lower cell numbers in the peritoneum of C5ar1−/− mice when compared to wt animals.