To analyze the role of RHOB in Vγ9Vδ2 T cell reactivity against NSCLC, we first screened the basal reactivity of Vγ9Vδ2 T cells against four cell lines with different mutation statuses: A549 (KRAS mutant), H1299 (HRAS mutant), PC9 and H827 (EGFR mutant). This evidence concerns the gene RHOB and non-small cell lung carcinoma.