On the other hand, the CD4+/IL-10+ T cell subpopulation was found to negatively correlate with Akkermansia, an organism that, as mentioned above, can exacerbate MS symptoms, probably either directly, by shifting immune responses toward a TH1 phenotype, or indirectly, by interacting with other bacteria and reducing their ability to drive Treg differentiation (77). This evidence concerns the gene CD4 and myeloid sarcoma.