The rodent models of cirrhosis and ACLF were also used to examine downstream signaling of mincle via FC receptor gamma chain (gene Fcer1g), spleen associated tyrosine kinase (gene Syk), caspase recruitment domain family member 9 (gene Card9) and nuclear factor kappa B (genes Nfkb1 and NFkb2) in liver and in circulating immune cells via transcriptome analysis (Figure 2C). Here, SYK is linked to Cirrhosis.