Compared to macrophages isolated from wild-type mice, CD11b+F4/80+ peritoneal macrophages (thioglycolate stimulated) from signal transducer and activator of transcription (STAT) 3 knockout mice were able to stimulate more potent OT-1 CD8+ T lymphocyte proliferation and IFN-γ production in vitro with irradiated tumor cells expressing ovalbumin (65). The gene discussed is ITGAM; the disease is neoplasm.