Supporting a functional role in the tumor environment, these cells are efficient at B16 tumor cell uptake (GFP-labeled), and in vivo blocking of CSF1R-positive cells (blocking most macrophages, including the new DC macrophage hybrid subset) significantly decreased antigen cross-presentation to ovalbumin-specific OT-I CD8+ T lymphocytes (proliferation) (56). The gene discussed is CSF1R; the disease is neoplasm.