The expression of human SP-D was analyzed in eight cases of invasive ductal carcinoma, no special type (NSP), comprising two cases for each molecular class (luminal A, luminal B, Her2-Neu, and triple negative) based on the expression of the estrogen receptor (ER), the progesterone receptor (PR), and the human EGF receptor 2 (Her2-Neu) status. This evidence concerns the gene ERBB2 and invasive ductal breast carcinoma.