NAAA and cystic fibrosis: Although P. aeruginosa M18, PACS171b, and PACS88A were shown to produce pyoluteorin, genomic analysis of P. aeruginosa LESB58, a highly virulent clinical strain isolated from CF patients, revealed that the pltB gene within the plt biosynthetic gene cluster pltRM-pltLABCDEFG had a 5-bp deletion resulting in a truncated PltB protein and a defect in pyoluteorin biosynthesis (Winstanley et al., 2009).