The detrimental consequences are not hard to imagine when this life-threatening hyperinflammatory HBP-GlcNAc-OGT–IRF5-interferon-SARS-CoV-2 pathway from the COVID-19 pandemic meets with CLGSPI found in common, complex highly prevalent pandemics such as obesity and diabetes, also found in not so old individuals with symptom-free adipose tissue dysfunction, insulin resistance, the metabolic syndrome and/or prediabetes (13, 47). This evidence concerns the gene IRF5 and obesity due to melanocortin 4 receptor deficiency.