Respiratory epithelial cells, dendritic cells (DCs) and macrophages (1) secrete low levels of the antiviral factor interferons (IFNs) (2) and high levels of proinflammatory cytokines such as tumor necrosis factor alpha (TNFα), IL-6, and IL-1β, IP-10, MCP-3, characterizing the pathophysiologic features of severe acute respiratory syndrome (ARDS) induced by SARS-CoV-2 infection (3). Here, TNF is linked to acute respiratory distress syndrome.