• aMCI and MA-MCI ApoE4/4 carriers (phase III, IV) • Mild AD ApoE4/4 carriers (phase III, IV) • ApoE4/4 carriers with non-AD neurodegenerative disorders:    ∘ Lewy Body Disease (phase II, III, IV)    ∘ Vascular dementia (phase II, III, IV)    ∘ Frontotemporal dementia (phase II, III, IV)    ∘ Parkinson-dementia (phase II, III, IV). The gene discussed is APOE; the disease is Alzheimer disease.