Accordingly, enhanced expression of various cytokines, including interleukin (IL)-1β, tumor necrosis factor (TNF), IL-6, IL-17, and interferon (IFN)-γ has been reported in animal models (i.e., experimental autoimmune encephalomyelitis, EAE) and in the perivascular infiltrates and cerebrospinal fluid (CSF) of MS patients (90–94). Here, TNF is linked to myeloid sarcoma.