TNF and experimental autoimmune encephalomyelitis: Accordingly, enhanced expression of various cytokines, including interleukin (IL)-1β, tumor necrosis factor (TNF), IL-6, IL-17, and interferon (IFN)-γ has been reported in animal models (i.e., experimental autoimmune encephalomyelitis, EAE) and in the perivascular infiltrates and cerebrospinal fluid (CSF) of MS patients (90–94).