IGF1R and diabetes mellitus: However, the expression of miR-223 was restored by treatment with calpeptin and AgomiR-223, suggesting that inhibition of calpain restores the expression of miR-223 in injured DM mice (Figure 6E).Collectively, these data demonstrate that calpeptin restores the downregulated miR-223 in diabetic platelets and transferred more platelet-derived miR-223 into VSMC, thereby suppressing VSMC proliferation through targeting IGF-1R in the injured vessel, resulting in alleviation of neointimal formation in diabetes.