The downregulation of PTEN is associated with increased lipid endocytosis in podocytes from patients with obesity-related glomerulopathy, in cultured mouse podocytes with PTEN knock-down and in mice with podocyte-specific knockout of PTEN, thus enhancing the uptake of lipids and causing podocyte injury and proteinuria through oxidative stress response (Shi et al., 2019). The gene discussed is PTEN; the disease is obesity due to melanocortin 4 receptor deficiency.