On the other hand, Erkens et al. (2018) reported that global KO of Nrf2 attenuates myocardial ischemia-reperfusion injury and dysfunction most likely due to an increase in cardiac nitric oxide (NO) production in mice, revealing a detrimental effect of Nrf2-mediated suppression of NO production to the heart. This evidence concerns the gene NFE2L2 and myocardial ischemia.