Comparable results were obtained by Edwardson et al. (2017) with a cross-sectional analysis using an iso-temporal substitution model in a large group of individuals considered at risk of impaired glucose tolerance or diabetes and a 7-day objective sitting/standing/stepping monitoring with ActivPal; they concluded that a model of reallocation of prolonged sitting bouts to shorter bouts or standing produces significant increase of insulin sensitivity and reduction of blood fasting insulin levels after a 2-h glucose loading test. This evidence concerns the gene INS and Impaired glucose tolerance.