It is also known that the activation of several oxidative stress-related inflammatory signaling pathways, such as NF-E2 p45 related factors 2 (Nrf2) and heme oxygenase-1 (HO-1), is related to inflammation in AD (Choi et al., 2014; Akram et al., 2016). The gene discussed is HMOX1; the disease is Alzheimer disease.