The CF airway milieu is typified by high concentrations of several proteases including neutrophil serine proteases: NE, proteinase 3, Cathepsin G; lysosomal proteases: Cathepsins B, L, and S; and matrix metalloproteases: MMP-9, MMP-8 and MMP-12 (McKelvey et al., 2019) which stimulate downstream signaling cascades that perpetuate oxidative stress and inflammation. Here, PRTN3 is linked to cystic fibrosis.