Another study in murine xenograft models of non-small cell lung cancer (NSCLC) using A549 and H1975 cells showed BFD could inhibit tumor growth and prolong the survival in mice by blocking the crosstalk between TAMs and cancer cells through decreasing IL-10 and PD-L1 in vitro and in vivo (Pang et al., 2017). This evidence concerns the gene CD274 and neoplasm.