Previous studies reported that, GJA1 encoded Cx43 plays a critical role in intercellular communication between cardiomyocytes (Basheer et al., 2018), COL1A1 encoded collagen-I chains involved in ventricular arrhythmia (Yao et al., 2020), moreover, KCNH2 encoded the voltage-gated potassium channel, which is a critical current for the repolarization phase of the APD (Mazzanti et al., 2017). The gene discussed is KCNH2; the disease is Ventricular arrhythmia.