As shown in Figures 6B, C, the expression of Cx43 in MetS group were obviously decreased when compared to the CTL group (P < 0.01, Figures 6B, C), administration of SSYX in MetS rats significantly increased Cx43 expression compared with MetS group (P < 0.05, Figures 6B, C). Here, GJA1 is linked to metabolic syndrome.