ORAI1 and breast cancer: Moreover, microarray analysis data show that, the basal-breast cancer, a breast cancer subtype with a very dismal prognosis, is correlated with an altered relationship between the ORAI1 activators STIM1 and STIM2, characterized by high STIM1/STIM2 ratios (McAndrew et al., 2011; Berna-Erro et al., 2017) (Table 1).