RUNX2 and ocular melanoma: Furthermore, following treatment with OM and CAPE for 48 h (Figure 2C) and 7 days (Figure 2D), the expression of RUNX2 and ALP at the protein level was significantly increased (* P < 0.05) compared with those detected in the control group (without OM and CAPE treatment), while the expression of these proteins was decreased compared to the levels detected in AVICs cultured in OM alone (# P < 0.05).