One hypothesis (Reiman et al., 2009; Lambert et al., 2013; Yu et al., 2019) for the pathogenesis (Karch and Goate, 2015) of AD indicate the apolipoprotein E (APOE) e4 allele (Lane-Donovan and Herz, 2017) involves the accumulation of Amyloid-β (Caselli et al., 2010), leading to increasing neuronal atrophy and synapse loss. This evidence concerns the gene APOE and Alzheimer disease.