Only within two active and demyelinating subpial GM lesions of MS160 case, a very rare finding in chronic MS, a high density of TNFR2+ CD68+ foamy macrophages and activated microglia was observed (Figure 7E); TNFR2+ CD68+ cells accounted for 29 to 50% (median value 43%) of intralesional CD68+ cells. This evidence concerns the gene TNFRSF1B and myeloid sarcoma.