In the MS GM, TNFR2 immunoreactivity was detected mainly in foamy macrophages within active and demyelinating GM lesions, a very rare finding in progressive MS, suggesting higher expression of this receptor on microglia/macrophages during early disease phases when inflammatory cortical demyelination is more prominent (Lucchinetti et al., 2011). This evidence concerns the gene TNFRSF1B and Peripheral demyelination.