Having found that TNFR2, a receptor implicated in TNF-mediated anti-inflammatory and regenerative processes in the CNS, was upregulated at the transcriptional level in all WM areas analyzed, we performed a detailed study of the distribution and cellular localization of TNFR2 in the MS brain using immunohistochemical techniques. Here, TNFRSF1B is linked to myeloid sarcoma.