TNF and myeloid sarcoma: Because increasing evidence supports a neuroprotective role for TNFR2-mediated TNF signaling in different experimental models of CNS injury (Suvannavejh et al., 2000; Arnett et al., 2001; Fontaine et al., 2002; Brambilla et al., 2011; Taoufik et al., 2011; Patel et al., 2012; Probert, 2015; Dong et al., 2016; Madsen et al., 2016; Gao et al., 2017), we deemed important to define precisely the cellular localization of TNFR2 and its relation to lesion evolution in the MS brain using immunohistochemical techniques.