Many of the selected genes are inducible by IFNγ (Langlais et al., 2016), which is a major trigger of microglia/macrophage effector functions involved in antimicrobial defenses and is produced by MS brain-infiltrating immune cells (Serafini et al., 2007; Magliozzi et al., 2018; Veroni et al., 2018). This evidence concerns the gene IFNG and myeloid sarcoma.