Since ablation of microglial TNFR2 was shown to increase demyelination in experimental autoimmune encephalomyelitis (Gao et al., 2017), analysis of cerebellar slices obtained from mice with TNFR2 deletion in microglia should help clarify the contribution of this glial cell population to TNFR2-activated remyelinating pathways. The gene discussed is TNFRSF1B; the disease is experimental autoimmune encephalomyelitis.