PLEKHG5 and amyotrophic lateral sclerosis: Mutations within the human PLEKHG5 gene are associated with different motoneuron diseases, such as an intermediate form of CMT, distal spinal muscular atrophy (DSMA) type IV, and amyotrophic lateral sclerosis (ALS; Maystadt et al., 2007; Azzedine et al., 2013; Kim et al., 2013; Özoğuz et al., 2015).