These inclusions are generally associated with neurotoxicity, and inclusion burden in cortical and limbic regions is associated with the manifestation of cognitive and neuropsychiatric symptoms, a feature that spans both sporadic disease and LRRK2-PD (Aarsland et al., 2005; Braak et al., 2005; Goldwurm et al., 2006; Smith et al., 2019). The gene discussed is LRRK2; the disease is Parkinson disease.