MAPT and Alzheimer disease: The later are constituted by hyperphosphorylated microtubular tau protein (Nussbaum and Ellis, 2003), while the Aβ peptides present in the senile plaques of AD individuals are cleavage products of the β-amyloid protein precursor by a group a proteases, namely the γ-, β-, and α-secretases (Hutton et al., 1998).