Additional mechanisms promoting an inflammatory response that subsequently perturbs the brain redox balance are: (1) abnormal mitochondrial dysfunction (Rego and Oliveira, 2003) due to mutations, such as leucine-rich repeat kinase 2(LRRK2), PINK1, DJ1, and α-synuclein associated to PD (Zuo and Motherwell, 2013); (2) brain-infection due to microbial exposure (e.g., by Candida albicans, Salmonella enterica) (Stilling and Cryan, 2016) or by proinflammatory microbial-metabolites that migrate and are capable of reaching the brain (Wekerle, 2018). This evidence concerns the gene LRRK2 and Parkinson disease.