Research has shown that antisense foci were observed to be higher in the Purkinje neurons in cerebellum and motor neurons whereas sense foci were significantly increased in the granule neurons in the cerebellum obtained post mortem from C9orf72-related ALS or C9orf72-related ALS-FTD patients, as detected by fluorescence in situ hybridization (Cooper-Knock et al., 2014, 2015b) and RT-PCR (Zu et al., 2013). The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.