OPTN and frontotemporal dementia: OPTN is involved in several cellular functions including autophagy, vesicular trafficking, Golgi maintenance [as evident from Golgi apparatus fragmentation in spinal motor neurons and glia in post mortem tissue obtained from an ALS-FTD patient (Kamada et al., 2014) and neuroinflammation (Toth and Atkin, 2018; McCauley and Baloh, 2019)].