ALS-linked mutations in UBQLN2 gene were also found to be associated with dysfunction of autophagy, neuroinflammation, as well as the formation of stress granules, where mutations disrupted interaction with FUS (ALS6) and FUS-RNA complexes (Picher-Martel et al., 2015; Hjerpe et al., 2016; Alexander et al., 2018; Dao et al., 2018; Renaud et al., 2019). Here, FUS is linked to amyotrophic lateral sclerosis.