ATXN2 and amyotrophic lateral sclerosis: Many of the additional ALS genes can also be categorized into these pathways (Table 1 and Figure 2), such as SETX, ANG, ATXN2, hnRNPA1, and MATR3, which are all involved in RNA processing and SPG11, KIF5A, and PFN1 that are associated with the cytoskeleton and mutations in which cause axonal defects (Alsultan et al., 2016).