Mutations in VCP account for 1–2% of fALS cases, are found to be rare in sALS (Koppers et al., 2012) and whilst FTD is recognized in a third of IBMPFD patients, mutations have been found in FTD cases (Saracino et al., 2018; Wong et al., 2018). This evidence concerns the gene VCP and frontotemporal dementia.