A majority of the mutations in VCP have been documented in the N-domain in patients with ALS and/or FTD (Abrahao et al., 2016; Wang et al., 2016; Shahheydari et al., 2017) although additional ALS and FTD mutations have been reported in the D1 domain (Wong et al., 2018). Here, VCP is linked to amyotrophic lateral sclerosis.