Ubiquitinated aggregates of TDP-43 are found in the cytoplasm of MNs of ALS and FTD patients, not just patients with TARDBP mutations (Neumann et al., 2006; Mackenzie and Rademakers, 2008; Johnson et al., 2009; Kirby et al., 2010). Here, TARDBP is linked to amyotrophic lateral sclerosis.