SQSTM1 and amyotrophic lateral sclerosis: DPR inclusions stain positive for p62 (SQSTM1), which is a component of ubiquitin-proteasome system (and which is also mutated in ALS-FTD) whilst TDP-43 pathology is found to be variable, with TDP-43 inclusions not always present in the same neurons as DPR inclusions (Cooper-Knock et al., 2012, 2015a; Mann et al., 2013; Schludi et al., 2015; Hautbergue et al., 2017).