Furthermore, several studies report about the overactivation of the PI3K/Akt/mTOR pathway that occurs during the early phases of AD (Pei et al., 2008; Caccamo et al., 2010; Tramutola et al., 2015), leading to impaired glucose metabolism, defects in energy production, and aberrant regulation of protein synthesis and degradation (Oddo, 2012; Tramutola et al., 2015; Di Domenico et al., 2017). The gene discussed is AKT1; the disease is Alzheimer disease.