In light of the role of the insulin signaling pathway in regulating synaptic plasticity and cognitive functions, alterations of proteins belonging to the insulin signaling but not APP cleavage products or TNFα levels were significantly associated with reduced synaptic proteins levels, i.e., syntaxin and postsynaptic density 95 (PSD95), in DS with respect to age-matched control (Tramutola et al., 2020). This evidence concerns the gene APP and Dravet syndrome.