INS and Dravet syndrome: Moreover, considering that insulin signaling activation regulates mitochondrial functions (Butterfield et al., 2014a; Abad et al., 2019; Wardelmann et al., 2019) and that mitochondria are dysfunctional in DS (Mollo et al., 2020), it is conceivable to think rescuing insulin signaling activation in DS would be beneficial also with respect to mitochondrial performances.