IRS1 and Alzheimer disease: Loss of BVR-A leads to the hyper-activation of IRS1 without a concomitant activation of Akt downstream from IRS1 in animal model of AD (Triani et al., 2018; Sharma et al., 2019) as well as in vitro (Miralem et al., 2016; Sharma et al., 2019), suggesting an overall uncoupling among the proteins responsible for insulin action within the cells.