As reported by our group, intranasal rapamycin (a well-known mTOR inhibitor; Guertin and Sabatini, 2009) administration to Ts65Dn mice promoted neuroprotective effects including reduced AD pathological hallmarks (Aβ and Tau levels), reduced oxidative stress levels, and increased synaptic proteins levels and amelioration of cognitive functions (Tramutola et al., 2018; Di Domenico et al., 2019). Here, MTOR is linked to Alzheimer disease.