Aberrant mTOR activation is associated with increased AD neuropathological markers both in humans and animal models of the pathology (Caccamo et al., 2010, 2011; Orr et al., 2014; Tramutola et al., 2015; Barone et al., 2016, 2019; Triani et al., 2018). Here, MTOR is linked to Alzheimer disease.