In contrast, well-differentiated tumours had lower rate of TP53 mutations compared to moderate- and poorly differentiated tumours (OR 0.24, 95%CI: 0.1–0.9, P = 0.0290 and OR 0.22, 95%CI: 0.1–0.7, P = 0.0154) (Ptrend < 0.0383) (Fig. 3) (see Data Supplement Table S4). Here, TP53 is linked to neoplasm.