GNAS and neoplasm: Well- and moderately differentiated tumours were enriched for RAS (OR 3.31, 95%CI: 1.4–7.2, P = 0.0058 and OR 2.61, 95%CI: 1.2–5.4, P = 0.0116) (Ptrend = 0.0033) and GNAS (OR 7.67, 95%CI: 2.9–20.0, P < 0.0001 and OR 4.18, 95%CI: 1.6–10.6, P = 0.0026) (Ptrend < 0.0001) compared to poorly differentiated tumours (Fig. 3) (see Data Supplement Table S4).