This discrepancy between proportion of patient with RAS/GNAS mutations identified by blood compared to tissue NGS was seen more in well-differentiated (0.0% vs. 67.7%; OR 0.00, 95%CI: 0.0–0.4, P < 0.0001) and moderately differentiated (0.0% vs. 71.1%; OR 0.00, 95%CI: 0.0–0.4, P = 0.0017) tumours as compared to poorly differentiated tumours (25.0% vs. 43.4%; OR 0.33, 95%CI: 0.0–2.2, P = 0.393). The gene discussed is GNAS; the disease is neoplasm.