Methylation in PRICKLE4 (p value sex interaction = 1.26 × 10−09), GFAP (p value sex interaction = 6.88 × 10−05), RP11-1E3.1 (p value sex interaction = 1.11 × 10−07) and UBB (p value sex interaction = 1.54 × 10−11) was only associated with MDD in men, but not in women or in both men and women (Table 3). Here, GFAP is linked to major depressive disorder.