Notably, in our study, we demonstrate that p53-R273H inhibits KLF6 expression to promote cell migration and tumor metastasis in E-cadherin-dependent or independent fashion, as KLF6 can repress expression of VAV315, E2F116, or MMP917 involved in tumor metastasis (Fig. 5g). The gene discussed is KLF6; the disease is neoplasm.