In this study, the mIDH1 inhibitor BAY1436032 was evaluated at 4 different dose levels in a total of 27 AML subjects who harbored a mutation which altered the residue at position R132 of IDH1 to any one of 5 different amino acids, each of which is known to generate the R-2HG oncometabolite and to be inhibited by BAY1436032 [16, 17]. This evidence concerns the gene IDH1 and acute myeloid leukemia.