Studies showed that pharmacological activation or overexpression of ALDH2 provided cardio-protection against ischemia and atherosclerosis by detoxification of reactive aldehydes30,31, however, another study showed that overexpression of aldehyde dehydrogenase 2 could even exacerbate cardiac remodeling in the setting of pressure overload32. The gene discussed is ALDH2; the disease is ischemia.