Deficiency of ALDH2 resulted in worse cardiac hypertrophy and fibrosis in pressure overload mice (Fig. 5g–i, Supplementary Fig. S2C–E) both in α-LA treated group and vehicle treated group, suggesting that the attenuating-remodeling effects of α-LA are largely mediated by ALDH2. The gene discussed is ALDH2; the disease is cardiac hypertrophy.