HAMP and rheumatoid arthritis: AUR is approved for use in treating rheumatoid arthritis (RA) due to its anti-inflammatory activity.47 Based on our results from screening a total of 14 anti-RA drugs (10 of which significantly upregulated or downregulated hepcidin expression), we found that AUR, fenbufen, rofecoxib, sulindac, and ketoprofen robustly upregulated hepcidin expression in Huh7 cells (defined as a >5-fold increase in HAMP1 mRNA compared to control-treated cells).